Regenerating the liver: not so simple after all? [version 1; referees: 3 approved]

Regenerating the liver: not so simple after all? [version 1; referees: 3 approved]

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Under normal homeostatic conditions, hepatocyte renewal is a slow process and complete turnover likely takes at least a year.Studies of hepatocyte regeneration after a two-thirds partial hepatectomy (2/3 PH) have strongly suggested that periportal hepatocytes are the driving force behind regenerative re-population, nautilus xpload lat pulldown but recent murine studies have brought greater complexity to the issue.Although periportal hepatocytes are still considered pre-eminent in the response to 2/3 PH, new studies suggest that normal homeostatic renewal is driven by pericentral hepatocytes under the control of Wnts, while pericentral injury provokes the clonal expansion of a subpopulation of periportal hepatocytes expressing low levels of biliary duct genes such as Sox9 and osteopontin.Furthermore, some clarity has been given to the debate on the ability of biliary-derived hepatic progenitor cells to corsa exhaust scat pack charger generate physiologically meaningful numbers of hepatocytes in injury models, demonstrating that under appropriate circumstances these cells can re-populate the whole liver.